Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis
نویسندگان
چکیده
Extensively drug-resistant (XDR) tuberculosis (TB) is defined by resistance to isoniazid, rifampicin, any fluoroquinolone and at least one of the three second line injectable drugs, such as amikacin. Drug toxicity and duration impair adherence to treatment and outcome is rather poor [1]. We report on a particularly challenging XDR-TB patient with persistent non-adherence to treatment and an exceptionally complex drug susceptibility pattern.
منابع مشابه
Nanomedicine for tuberculosis: Insights from animal models
Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...
متن کاملNanomedicine for tuberculosis: Insights from animal models
Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...
متن کاملPatterns of Drug Resistance Among Tuberculosis Patients in West and Northwestern Iran
BACKGROUND Tuberculosis (TB) is the leading cause of morbidity and mortality among chronic infectious diseases. OBJECTIVE The goal of this cross-sectional study (2011-2013;2013) was to examine the patterns of TB drug resistance among HIV-negative pulmonary TB patients in regions near the Iranian border. METHOD To this end, MTB isolates were harvested from 300 HIV-negative, pulmonary smear-p...
متن کاملIndividualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia.
Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-bur...
متن کاملMediastinoscopy after negative endoscopic mediastinal nodal staging: can it be omitted?
References 1 World Health Organization. Companion Handbook to the WHO Guidelines for Programmatic Management of Drug Resistant Tuberculosis. WHO/HTM/TB/2014.11. Geneva, WHO, 2014. 2 Cox HS, Furin J, Mitnick CD, et al. The need to accelerate access to new drugs for multidrug-resistant tuberculosis. Bull World Health Organ 2015; 93: 491–497. 3 Isaakidis P, Cox HS, Varghese B, et al. Ambulatory mu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 51 شماره
صفحات -
تاریخ انتشار 2018